How To Uninstall Wine From Mac OS X

Uninstalling Wine and Homebrew

If you use Wine and you don't like it, uninstalling it is easy. Just run this command:

brew uninstall wine

And Homebrew will helpfully remove Wine from your computer. 

Note: in order to install Wine, Homebrew also install many other small programs that Wine relies upon to work correctly. if you want to remove these as well, download and run the Homebrew uninstallation script.